The serum proteins in multiple myelomatosis

Abnormal lipoproteins in multiple myelomatosis.

In a study of the lipoprotein pattern in multiple myelomatosis electrophoresis on agarose gel showed abnormal lipoproteins, named paralipoproteins (p-Lp), in 24 out of 30 normolipidaemic patients. These paralipoproteins were grouped according to their mobility into one or another of the following types: (1) p-Lp1 with a mobility identical with that of gamma-globulin, (2) p-Lp2 with a mobility b...

Multiple myelomatosis with proptosis.

MULTIPLE myelomata are uncommon endosteal tumours developing from the myeloblastic elements of the bone marrow. The ribs, sternum, clavicle, vertebral bodies, and pelvis are favourite sites; the skull is also frequently involved and the long bones may be affected, but never alone (Perkins, 1936). The disease has an insidious onset and is often only recognized late when multiple nodules appear o...

May 1948 STEVENSON - : Multiple Myelomatosis

Bear this disease in mind when treating pains of the limbs of an obscure and intractable character.' This was said by Thos. Blizard Curling, F.R.S., Surgeon to the London Hospital, to William Macintyre i00 years ago. The quotation is from the paper in which Macintyre published at his leisure in i850 the clinical history of a case which had been noted to have ' urine of high density containing m...

Ophthalmological complications of multiple myelomatosis.

Electrophoretic analysis of serum and urinary proteins in the diagnosis of myelomatosis.

Electrophoresis, using either the classical method of Tiselius or zone electrophoresis on paper, has been widely employed in the study of serum and urinary proteins in myelomatosis, but so far few investigators have examined the diagnostic value of this procedure. In an attempt to make such an assessment, we have compared critically the results of electrophoretic analyses of serum and urinary p...